Current Medication Data

IV Medication    pH osm/L      
acyclovir (zovirax)    10.5 - 11.6 316          

Submitted by: Lynda DeLuca RN
Reference: http://reference.medscape.com/drug/zovirax-acyclovir-342601#11
Comments: IV Incompatibilities
Blood products & protein-containing solutions
Additive: dobutamine, dopamine, meropenem(?)
Syringe: caffeine
Y-site: amifostine, amsacrine, aztreonam, cefepime, dobutamine, dopamine, fludarabine, foscarnet, gemcitabine, idarubicin, levofloxacin, morphine sulfate(?), ondansetron, piperacillin/tazobactam, sargramostim, vinorelbine
IV Compatibilities
Additive: fluconazole
Y-site (partial list): allopurinol, ampicillin, cefazolin, cimetidine, diphenhydramine, fluconazole, heparin, linezolid, lorazepam, MgSO4, KCl, propofol, TMP-SMX, vancomycin
IV Preparation
Reconstitution: concentrations >10 mg/mL increase the risk of phlebitis; usual recommended concentration is NMT 7 mg/mL in D5W
IV Administration
For IV infusion only
Avoid rapid infusion
Infuse over 1 hr at a constant rate to prevent renal damage
Maintain adequate hydration of pt
Check for phlebitis & rotate infusion sites
Storage
Reconstituted solutions remain stable for 24 hr at room temp
Avoid refrigerating reconstituted solutions to prevent precipitation


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